When it comes to managing diabetes, there are various treatment options available. Among these options, two commonly prescribed medications are Jardiance and Januvia. Both Jardiance and Januvia are oral medications that are used to control blood sugar levels in people with type 2 diabetes. However, there are some key differences between these two medications that individuals should be aware of when considering their treatment options. This article will explore the differences between Jardiance and Januvia, including their mechanisms of action, side effects, and effectiveness.

What is Jardiance?

Jardiance, also known by its generic name empagliflozin, is a medication that belongs to a class of drugs called sodium-glucose co-transporter-2 (SGLT2) inhibitors. It works by blocking the reabsorption of glucose in the kidneys, allowing excess glucose to be excreted through urine. By lowering blood sugar levels, Jardiance helps individuals with type 2 diabetes maintain better glycemic control.


What is Januvia?

Januvia, or sitagliptin, is a medication that falls under the class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. Unlike Jardiance, Januvia works by inhibiting an enzyme in the body called DPP-4. By blocking this enzyme, Januvia increases the levels of incretin hormones, which stimulate the release of insulin and reduce the production of glucose by the liver. This mechanism helps lower blood sugar levels in individuals with type 2 diabetes.

Mechanism of Action

The main difference between Jardiance and Januvia lies in their mechanism of action. While Jardiance primarily targets the kidneys to eliminate excess glucose from the body, Januvia focuses on enhancing the body's natural production of insulin and reducing glucose production in the liver. Both medications work to lower blood sugar levels, but they achieve this through different pathways.

Side Effects

As with any medication, Jardiance and Januvia may cause side effects in some individuals. It is important to consult with a healthcare professional before starting any new medication to understand the potential risks and benefits.

Jardiance may cause some common side effects such as urinary tract infections, genital yeast infections, and increased urination. In rare cases, it may also lead to dehydration, low blood pressure, and an increased risk of ketoacidosis.

On the other hand, the most common side effects associated with Januvia include upper respiratory tract infections, headaches, and stomach discomfort. In rare cases, it may also lead to pancreatitis and severe joint pain.


Both Jardiance and Januvia have been proven to be effective in managing blood sugar levels in individuals with type 2 diabetes. However, studies have shown that Jardiance has an additional benefit of reducing the risk of cardiovascular events such as heart attacks and strokes, making it a preferred choice for individuals with a high risk of cardiovascular diseases.

Furthermore, Jardiance has also demonstrated benefits in reducing the risk of overall mortality and hospitalization due to heart failure, while Januvia has not shown similar effects. Therefore, for individuals with both diabetes and a high risk of cardiovascular complications, Jardiance may be a more appropriate medication.

Choosing Between Jardiance and Januvia

Selecting the most suitable medication for managing diabetes requires careful consideration of individual factors and preferences. Consulting with a healthcare professional is crucial in making an informed decision. Factors such as overall health, risk of cardiovascular diseases, potential side effects, and cost should all be taken into account when choosing between Jardiance and Januvia.

It is important to note that Jardiance and Januvia are not the only treatment options available. There are several other medications and lifestyle modifications that can help individuals with type 2 diabetes manage their condition effectively. Working closely with a healthcare team can provide comprehensive guidance on the most appropriate treatment plan.


In summary, Jardiance and Januvia are medications commonly used to manage type 2 diabetes. Jardiance works by blocking glucose reabsorption in the kidneys, while Januvia enhances the body's natural insulin production. While both medications effectively lower blood sugar levels, Jardiance has the added benefit of reducing the risk of cardiovascular events.

Ultimately, the choice between Jardiance and Januvia depends on individual factors and should be made in consultation with a healthcare professional. By understanding the differences between these medications and considering personal circumstances, individuals can make an informed decision about their diabetes management plan.

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